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Table 3 Performance of CO-RADS

From: The role of chest imaging in the diagnosis, management, and monitoring of coronavirus disease 2019 (COVID-19)

First author [reference] Country Inclusion period [in 2020] No. of patient RT-PCR positivity (%) CO-RADS 5 ≥ CO-RADS 4 ≥ CO-RADS 3
Sen Spe PPV NPV Sen (%) Spe (%) PPV (%) NPV (%) Sen Spe PPV NPV
de Jaegere [68] Netherlands 3/12–3/23 96 47 62% 98% 96% 75% 84 92 91 87
Hermans [69] Netherlands 3/27–4/20 319 42 75% 94% 90% 84% 90 88 85 93 93% 66% 66% 93%
De Smet [70] Belgium 3/19–4/20 859 42 78% 93% 89% 86% 85 85 80 89 89% 85% 69% 90%
Fujioka [71] Japan Jan-Jun 154 49 53% 94% 90% 67% 68 88 85 74
Korevaar [72] Netherlands 3/16–4/16 239 47 93 70 73 92 97% 51% 64% 96%
Bellini [73] Italy 3/9–5/3 572 23 61 81 50 87
Tucato [74] Italy Unspecified 120 43 91% 91% 92% 90% 75 75 77 72 74% 76% 77% 72%
Nivet [75] France 3/13–4/14 513 48 79% 97% 96% 84% 92 84 84 92 96% 43% 60% 92%
Inui [49] Japan 1/30–6/30 100 50 65% 89% 86% 72% 86 68 73 83 91% 54% 66% 86%
Lieveld [76] Neherlands 3/19–3/28 741 50 89 87 76 95 95% 54% 49% 96%
Schalekamp [77] Netherlands 3/20–4/3 1070 50 71% 88% 86% 75% 86 81 82 85 92% 66% 73% 89%
Gross [78] Germany 3/22–4/7 96 20 80% 99% 95% 95% 90 91 71 97 90% 63% 38% 96%
  1. CO-RADS the COVID-19 reporting and data system, RT-PCR real-time reverse transcription polymerase chain reaction; Sen, sensitivity, Spe specificity, PPV positive predictive value, NPV negative predictive value