| | |
Healthy volunteers & CKD stage 1–3
|
CKD stage 1–3 & CKD stage 4–5
|
|---|
|
AUC (95% CI)
|
Cut-off
|
Sensitivity (%)
|
Specificity (%)
|
AUC (95% CI)
|
Cut-off
|
Sensitivity (%)
|
Specificity (%)
|
|---|
|
Cortex
|
T2*
|
0.752 (0.626–0.853)
|
49.5
|
47.06
|
100
|
0.931 (0.838–0.980)
|
46.78
|
82.35
|
100
|
|
ADC
|
0.766 (0.641–0.864)
|
1.892
|
56.86
|
90.91
|
0.928 (0.834–0.978)
|
1.78
|
88.2
|
91.7
|
|
Dt
|
0.851 (0.738–0.929)
|
1.697
|
60.78
|
100
|
0.823 (0.706–0.907)
|
1.616
|
80.39
|
83.33
|
|
Dp
|
0.761 (0.636–0.860)
|
19.33
|
74.51
|
100
|
0.553 (0.422–0.679)
|
12.75
|
43.14
|
91.67
|
|
fp
|
0.638 (0.506–0.756)
|
0.213
|
49.02
|
100
|
0.707 (0.578–0.815)
|
0.217
|
50.98
|
100
|
|
Medulla
|
T2*
|
0.735 (0.608–0.839)
|
25.6
|
62.75
|
81.82
|
0.935 (0.843–0.981)
|
22.9
|
92.16
|
83.33
|
|
ADC
|
0.736 (0.609–0.840)
|
1.830
|
76.47
|
72.73
|
0.882 (0.775–0.949)
|
1.629
|
82.35
|
83.33
|
|
Dt
|
0.832 (0.716–0.915)
|
1.611
|
76.47
|
90.91
|
0.770 (0.647–0.867)
|
1.509
|
82.35
|
66.67
|
|
Dp
|
0.734 (0.607–0.839)
|
17.96
|
68.63
|
100
|
0.529 (0.399–0.656)
|
15.29
|
37.25
|
91.67
|
|
fp
|
0.679 (0.548–0.792)
|
0.193
|
60.78
|
100
|
0.646 (0.516–0.763)
|
0.192
|
41.18
|
100
|
- The unit of T2* is ms; ADC, Dt and Dp value are given as × 10–3mm2/s. The f value is dimensionless
- ROC receiver operating characteristic, AUC area under the receiver operating characteristic curve, CI confidence interval, ADC apparent diffusion coefficient, Dt pure diffusion coefficient, Dp perfusion-related diffusion coefficient, fp pseudodiffusion fraction
