Quantitative ultrasound shear wave elastography (USWE)-measured tissue stiffness correlates with PIRADS scoring of MRI and Gleason score on whole-mount histopathology of prostate cancer: implications for ultrasound image-guided targeting approach

Insights into Imaging

Table 3 Distribution of PI-RADs classification using MRI and tissue stiffness using USWE in low/intermediate risk and high risk cancer prostate cancers based on Gleason score

Measurements	Low/intermediate risk^# GS group (n = 97)	%	High risk^{^} GS group (n = 99)	%	Pearson Chi-square	Degree of freedom	P value
PI-RADS classification*using MRI
PI-RADS 3	13	13.4	3	3.0
PI-RADS 4	28	28.9	17	17.2	12.838	2	0.002
PI-RADS 5	56	57.7	79	79.8
Stiffness (in Kpa) using USWE
< 100	33	34.0	10	10.1
100–130	12	12.4	35	35.4	23.577	2	< 0.001
> 130	52	53.6	54	54.5

*PI-RADS classification 3 means intermediate probability of clinically significant prostate cancer, 4 means high probability and 5 means very high probability of clinically significant prostate cancer; # Gleason score 3 + 3 and 3 + 4 were considered as low/intermediate risk cancer