Reference | n | [18F]FLT/[18F]FDG LC primary Tumour uptake (SUV) | [18F]FLT/[18F]FDG different LC histotypes uptake (SUVmax) | Purpose | TNM stage | Reference standard | Findings | ||
---|---|---|---|---|---|---|---|---|---|
Buck et al. 2002 [16] | 30 | Mean SUVmax = 5.2 | SCLC (n = 1): 2.4 | Diagnosis | TxN0M0 (n = 1); TxN0M1 (n = 4); T1N0M0 (n = 2); T1N1M0 (n = 2); T2N0M0 (n = 1); T2bN0M0 (n = 1); T2N1M0 (n = 4); T2N2Mx (n = 1); T2N2M1 (n = 1); T3N0M0 (n = 1); T3N3M0 (n = 1); T4N1M0 (n = 1); T4N2M0 (n = 2) | Histopathology Ki-67 | [18F]FLT uptake was weak but easily detectable in Primary lesions. [18F]FLT is strongly correlated with Ki-67 in the malignant lesions | ||
Vesselle et al. 2002 [27] | 10 | SUVmean: 3.84 | LCC (n = 4): 5.29 SqCC (n = 3): 3.58 ADC (n = 2): 4.01 | Diagnosis | NA | Histopathology Ki-67 S-phase fraction (SPF) | [18F]FLT SUVmax was correlated with Ki-67 and SPF (r = 0.78, p = 0.0043) and (r = 0.69, p = 0.03), respectively | ||
Dittmann et al. 2003 [23] | 16 | [18F]FLT SUVmean: 4.0 [18F]FDG SUVmean: 6.9 | NA | Diagnosis | NA | Histopathology Ki-67 [18F]FDG | [18F]FDG uptake was significantly higher than [18F]FLT uptake (p = 0.0006). [18F]FLT accurately detected thoracic lesions. Detection of lesions in the liver and the bone marrow was hampered with high physiological [18F]FLT uptake | ||
Buck et al. 2003 [22] | 26 | [18F]FLT SUVmean: 1.8 [18F]FDG SUVmean: 4.1 | [18F]FLT: SCLC (N = 1): 2.4 [18F]FDG: SCLC (N = 1): 12.7 | Diagnosis | TxN0M0 (n = 1); TxN0M1 (n = 4); T1N0M0 (n = 1); T1N1M0 (n = 2); T2bN0M0 (n = 1); T2N1M0 (n = 4); T2N2Mx (n = 1); T3N0M0 (n = 1); T3N3M0 (n = 1); T4N2M0 (n = 2) | Histopathology Ki-67 [18F]FDG | [18F]FDG uptake was significantly higher than [18F]FLT uptake (p = 0.05) | ||
Cobben et al. 2004 [15] | 17 | [18F]FLT Median SUVmax: 2.7 [18F]FDG Median SUVmax: 8 | [18F]FLT: ADC (n = 4): 2.73 SqCC (n = 4): 2.55 [18F]FDG: ADC (n = 4): 7.38 SqCC (n = 4) = 9.83 | Diagnosis Staging | TxN2/3M1 (n = 1); T1N0M1 (n = 1); T2N0M0 (n = 1); T2N2M0 (n = 1); T2N2M1 (n = 1); T2N2/3M1 (n = 1); T2N3M1 (n = 1); T4N0M1 (n = 2); T4N1M1 (n = 1); T4N2M0 (n = 3); T4N2M1 (n = 3) | Histopathology [18F]FDG | [18F]FDG uptake was significantly higher than [18F]FLT uptake (p = 0.012).. Staging by [18F]FLT-PET was correct for 8 of 17 patients | ||
Buck et al. 2005 [17] | 47 | [18F]FLT SUVmean: 3.7 [18F]FLT SUVmax: 5.5 [18F]FDG SUVmean: 6 [18F]FDG SUVmax: 11 | [18F]FLT: ADC (n = 8): 4.34 SqCC (n = 6): 6 LCC (n = 1): 5.7 SCLC (n = 1): 2.4 [18F]FDG: ADC (n = 8): 8.11 SqCC (n = 6): 6.5 LCC (n = 1): 12.5 SCLC (n = 1): 12.7 | Diagnosis Staging | TcisN0M0 (n = 1); T1N0M0 (n = 2); T1N1M0 (n = 2); T1N3M0 (n = 1); T2N0M0 (n = 2); T2N1M0 (n = 5); T2N2M0 (n = 2); T3N0M0 (n = 1); T3N3M0 (n = 1); T4N1M0 (n = 1); T4N2M0 (n = 2); T4N3M0 (n = 1) | Histopathology [18F]FDG | [18F]FDG uptake was significantly higher than [18F]FLT uptake (p = 0.05). Clinical TNM stage was correctly identified in 67% of [18F]FLT scans, compared to 85% of [18F]FDG scans | ||
Yap et al. 2006 [24] | 22 | [18F]FLT SUVmax: 1.6 [18F]FDG SUVmax: 3.1 | [18F]FLT: ADC (n = 9): 1.11 SqCC (n = 3): 1.7 LCC (n = 1): 3.6 [18F]FDG: ADC (n = 9): 1.87 SqCC (n = 3): 3.53 LCC (n = 1) = 7 | Diagnosis Staging | 0 (n = 3); IA (n = 5); IB (n = 2); IIA (n = 1); IIIA (n = 2); IIIB (n = 2); IV (n = 7) | Histopathology Ki-67 [18F]FDG | [18F]FDG uptake was significantly higher than [18F]FLT uptake (p < 0.05) [18F]FLT overstaged (9%) of patients and understaged (36%) of patients whereas [18F]FDG overstaged (27%) of patients and understaged (14%) of patients | ||
Yamamoto et al. 2007 [25] | 18 | [18F]FLT SUVmean: 3.6 [18F]FDG SUVmean: 8.5 | [18F]FLT: ADC (n = 7): 3.43 SqCC (n = 5): 6.26 [18F]FDG: ADC (n = 7): 7.46 SqCC (n = 5) = 16.02 | Diagnosis | T1N0M0 (n = 8); T1N2M0 (n = 1); T2N0M0 (n = 4); T2N1M0 (n = 2); T2N2M0 (n = 1); T3N2M0 (n = 1); T4N0M0 (n = 1) | Histopathology Ki-67 [18F]FDG | [18F]FDG uptake was significantly higher than [18F]FLT uptake (p < 0.0003) | ||
Tian et al. 2008 [21] | 55 | [18F]FLT SUVmean: 3.54 [18F]FDG SUVmean: 8.13 | [18F]FLT: ADC (n = 10): 3.72 SqCC (n = 2): 4.4 [18F]FDG: ADC (n = 10): 7.76 SqCC (n = 2): 9 | Diagnosis with dual tracers [18F]FDG/[18F]FLT | NA | Histopathology [18F]FDG RECIST | The sensitivity and specificity of [18F]FDG and [18F]FLT were 87.5% and 58.97% and 68.75% and 76.92%, respectively. Improved sensitivity and specificity, 100% and 89.74%, respectively were shown with dual tracer [18F]FDG/[18F]FLT | ||
Yamamoto et al. 2008 [19] | 34 | [18F]FLT SUVmean: 3.5 [18F]FDG SUVmean: 11.4 | [18F]FLT: ADC (n = 16): 4.28 SqCC (n = 16): 5.57 SCLC (n = 2): 2.35 [18F]FDG: ADC (n = 16): 9.88 SqCC (n = 16): 12.72 SCLC (n = 2): 10.7 | Diagnosis Staging | T1N1M0 (n = 1); T1N2M0 (n = 1); T2N0M0 (N = 10); T2N0M1 (N = 1); T2N1M1 (N = 2); T2N2M0 (N = 2); T3N0M0 (n = 1); T3N1M0 (n = 1); T3N2M0 (n = 2); T4N0M0 (n = 2) | Histopathology [18F]FDG | [18F]FDG uptake was significantly higher than [18F]FLT uptake (P < 0.0001). [18F]FLT showed same sensitivity and higher specificity and accuracy than [18F]FDG | ||
Yang et al. 2010 [20] | 31 | [18F]FLT SUVmax: 4.2 [18F]FDG SUVmax: 7.7 | [18F]FLT: ADC (n = 13): 3.8 SqCC (n = 11) = 5.7 [18F]FDG: ADC (n = 13): 8.4 SqCC (n = 11) = 8.1 | Diagnosis Staging | T1N0 (n = 4); T1N1 (n = 5); T1N2 (n = 2); T2N0 (n = 6); T2N1 (n = 4); T2N2 (n = 2); T3N0 (n = 3); T3N1 (n = 3); T3N2 (n = 2) | Histopathology [18F]FDG | [18F]FLT showed significantly lower sensitivity (p = 0.031) for primary lesions. [18F]FLT showed better accuracy and specificity but lower sensitivity for nodal staging than [18F]FDG | ||
Xu et al. 2016 [26] | 14 | [18F]FLT SUVmean: 4.96 [18F]FDG SUVmean: 8.12 | [18F]FLT: ADC (n = 11): 5.14 SqCC (n = 3): 4.28 [18F]FDG: ADC (n = 11): 8.38 SqCC (n = 3): 7.13 | Staging | T3N0M0 (n = 4); T3N1M0 (n = 3); T3N1M1 (n = 2); T4N0M0 (n = 1); T4N0M1 (n = 1); T4N1Mx (n = 1); T4N1M0 (n = 1); T4N1M1 (n = 1) | Histopathology [18F]FDG | [18F]FDG uptake was significantly higher than [18F]FLT uptake (p = 0.01). [18F]FLT showed better accuracy and specificity but lower sensitivity for nodal staging than [18F]FDG | ||
Wang et al. 2016 [18] | 55 | [18F]FLT SUVmax: 2.9 [18F]FDG SUVmax: 6.8 | NA | Diagnosis | NA | Histopathology Ki-67 [18F]FDG | [18F]FDG uptake was significantly higher than [18F]FLT uptake (p < 0.001) [18F]FLT showed lower sensitivity (68.75%) compared with 87.8% for [18F]FDG but higher specificity (77%) than [18F]FDG (59%) [18F]FLT can distinguish cancer from other solitary pulmonary nodules [18F]FDG showed an overlap in detecting cancer and tuberculosis |