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Table 2 Primary clinical or mpMRI characteristics of prostatic abnormalities

From: Differential diagnosis of uncommon prostate diseases: combining mpMRI and clinical information

Prostatic abnormalities

Primary clinical or mpMRI characteristics

Acinar adenocarcinoma with/without other glandular neoplasms

Age: elderly men

PSA: sharply elevated

PI-RADS: suitable

BPH

Age: elderly men

PSA: slightly elevated

PI-RADS: suitable

Chronic prostatitis

PSA: slightly elevated

PI-RADS: suitable

Benign hyperplastic nodules outside the TZ

PSA: Slightly elevated

PI-RADS: unsuitable

Granulomatous prostatitis

Past relevant history: iatrogenic causes (after surgical operations or BCG therapy for urothelial carcinoma) and allergy

PSA: transiently elevated

PI-RADS: unavoidable

Prostate tuberculosis

Past relevant history: BCG therapy for urothelial carcinoma

Symptoms: active tuberculosis in other organs or systems

PSA: transiently elevated

PI-RADS: unsuitable

Abscess

Symptoms: fever, chills, urinary frequency and urgency, suprapubic pain, and pus cells on urine examination

PSA: transiently elevated

mpMRI findings: central necrosis in the interior presenting with hyperintensity on T2WI, hyperintensity on high b-value DWI, and low ADC, with rim enhancement in the exterior

PI-RADS: unsuitable

Mesenchymal tumors

Age: younger men

PSA: normal

mpMRI findings: hemorrhagic, cystic or necrotic changes with complete or incomplete capsule causing distinct mass effects

PI-RADS: unsuitable

Lymphoma

PSA: normal

Symptoms: LUTS, systemic symptoms (including fever, chills, night sweats, and weight loss)

PI-RADS: unavoidable

Prostatic cystadenoma

Age: large age range

mpMRI findings: cystic lesions

PI-RADS: unsuitable

  1. PSA prostate-specific antigen, PI-RADS Prostate Imaging Reporting and Data System, BPH benign prostatic hyperplasia, TZ transitional zone, BCG bacillus Calmette–Guérin, mpMRI multiparametric magnetic resonance imaging, T2WI T2-weighted imaging, DWI diffusion-weighted imaging, ADC apparent diffusion coefficient, LUTS lower urinary tract symptoms