CT and MRI radiomics of bone and soft-tissue sarcomas: a systematic review of reproducibility and validation strategies

Insights into Imaging

Table 1 Characteristics of the papers dealing with bone sarcomas included in the systematic review

First author	Year	Aim	Tumor	Design	Reference standard	Modality	Database size (n)	Public data	Segmentation
First author	Year	Aim	Tumor	Design	Reference standard	Modality	Database size (n)	Public data	Process	Style
Baidya Kayal [50]	2020	Therapy response	Osteosarcoma	Prospective	Histology	MRI	32	No	Manual	3D
Chen [29]	2020	Local relapse Metastatic relapse	Osteosarcoma	Retrospective	Histology Imaging	MRI	93	No	Manual	2D without MS
Dai [45]	2020	Histotype	Ewing sarcoma Osteosarcoma	Retrospective	Histology	MRI	66	No	Manual	2D without MS
Fritz [13]	2018	Benign versus malignant Grading	Chondroma Chondrosarcoma	Retrospective	Histology Imaging	MRI	116	No	Manual	2D without MS
Gitto [46]	2020	Grading	Chondrosarcoma	Retrospective	Histology	MRI	58	No	Manual	2D without MS
Li [32]	2019	Histotype	Chondrosarcoma Chordoma	Retrospective	Histology	MRI	210	No	Manual	3D
Lin [15]	2020	Therapy response	Osteosarcoma	Retrospective	Histology	CT	191	No	Manual	3D
Lisson [12]	2018	Benign versus malignant	Chondroma Chondrosarcoma	Retrospective	Histology Imaging	MRI	22	No	Semiautomatic	3D
Wu [16]	2018	Survival	Osteosarcoma	Retrospective	Follow-up	CT	150	No	Manual	3D
Yin [38]	2020	Local relapse	Chondrosarcoma	Retrospective	Histology Imaging	MRI	103	No	Manual	3D
Yin [28]	2019	Histotype	Chordoma Giant cell tumor	Retrospective	Histology	CT	95	No	Manual	3D
Zhao [22]	2019	Survival	Osteosarcoma	Retrospective	Follow-up	MRI	112	No	Manual	3D