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Insights into Imaging
Fig. 4 | Insights into Imaging

Fig. 4

From: Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part II: treatment indications and complications

Fig. 4

A 29-year-old man with a choroidal melanoma of the right eye treated with proton-beam radiotherapy. The patient underwent secondary enucleation about three years after radiotherapy. Axial a T2-weighted turbo spin-echo STIR and b contrast-enhanced fat-suppressed T1-weighted images display an intraocular lesion along the posterior aspect of globe (white arrows). On T2-weighted image, a central well-marginated hypointense area is detectable within the mass (white arrowhead); it represents radiotherapy-related necrosis and its low signal intensity is due to the dispersion of melanin pigment. On contrast-enhanced T1-weighted image, the above-mentioned area appears relatively hypointense (white arrowhead) compared to the surrounding enhancing viable neoplastic tissue. c Histological examination showing an “abrupt transition” between a radiotherapy-related necrotic area with dispersion of melanin pigment (on the right) and the vital tumor tissue (on the left) (H&E, original magnification 100×)

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