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Insights into Imaging
Fig. 14 | Insights into Imaging

Fig. 14

From: Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part II: treatment indications and complications

Fig. 14

A 37-year-old man with radiation-induced optic neuropathy after proton-beam radiotherapy for choroidal melanoma of the right eye. The same patient as in Fig. 9. a, b Axial T2-weighted turbo spin-echo STIR images show an intraocular lesion (white arrowhead in b) along the posterosuperior aspect of the globe. The right optic nerve appears thinned and slightly hyperintense (white arrows) compared to the contralateral one (white dotted arrows). c Histological examination showing the optic nerve tissue with diffuse degenerative changes: a diffuse fibrosis, extensively dissociating the nerve fibres is evident (H&E, original magnification 50×). d Histological detail showing the presence of fibrosis, microcalcifications and microcystic changes, affecting the optic nerve and consisting with a radiotherapy-related degenerative process (H&E, original magnification 150×)

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