Genetic features | Clinical implications |
---|---|
Non-random chromosome aberrations | |
Monosomy 3, gain of chromosome 8q | High metastatic risk |
Gain of chromosome 6p | Low metastatic risk |
Driver genes (mutations) | |
BAP1 | High metastatic risk, poor survival |
EIF1AX | Increased patient survival |
SF3B1 | Late-onset metastatic disease |
GNA11, GNAQ | No prognostic value, not linked to patient outcomes |