Skip to main content

Table 3 Chromosome aberrations and driver mutated genes in uveal melanoma and their prognostic implications

From: Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part I: MR imaging with pathologic correlation and technical considerations

Genetic features Clinical implications
Non-random chromosome aberrations  
 Monosomy 3, gain of chromosome 8q High metastatic risk
 Gain of chromosome 6p Low metastatic risk
Driver genes (mutations)  
 BAP1 High metastatic risk, poor survival
 EIF1AX Increased patient survival
 SF3B1 Late-onset metastatic disease
 GNA11, GNAQ No prognostic value, not linked to patient outcomes