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Osteomyelitis/intraosseous abscess
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Uneven inner margin; irregularly shaped and eccentrically located sequestrum; usually intramedullary located and larger than 2.0 cm; does not enhance in its central portion; penumbra sign may be present
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Fracture/stress reaction
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Fracture line may be present; lack of a nidus; Follow-up imaging can be helpful in doubtful cases because the bone marrow edema regress over time and the fracture consolidates
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Osteoblastoma
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Larger than 2.0 cm; less painful; fewer inflammatory changes and reactive sclerosis; smaller response to salicylates; grow progressively; malignant potential and may be associated with other tumors
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Glomus tumor
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Well-defined nodule in the nail bed; no thickening of the rest of the nail bed or matrix; may exhibit well-defined remodeling of the dorsal cortical of the distal phalanx
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Chondroblastoma
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Epiphyseal intramedullary location; lobulated contours; larger dimensions; chondral calcifications and signal intensity
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