Table 3 Impacts of non-malignant lesion selection within TL or NTL group according to the primary endpoint captured by the assessment
From: RECIST 1.1 and lesion selection: How to deal with ambiguity at baseline?
Baseline equivocal lesions pooled as | Remaining lesion | Response-Related Endpoint impact | Progression-Related Endpoint impact |
|---|---|---|---|
TL | At least 1 other TL With or without NTL | Prevents a CR Limited impact on PR only if %NMTL < 20% | Delayed (or no) DOP Limited impact only if %NMTL < 20% and no initial response |
No other TL No other NTL | Simulates a SD and prevents a CR* | No impact | |
No other TL At least 1 NTL | Prevents a CR | No impact | |
NTL | With or without TL | Prevents a CR | No impact |