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Table 5 The diagnostic performance of BI-RADS with mammography, BI-RADS with tomosynthesis, and BI-RADS with combined tomosynthesis and mammography for confident breast cancer diagnosis considered BI-RADS 4 and 5 as predictive of malignancy

From: The added value of digital breast tomosynthesis in improving diagnostic performance of BI-RADS categorization of mammographically indeterminate breast lesions

Criterion

Mammography

Tomosynthesis

Combined

%

95% CI

%

95% CI

%

95% CI

Accuracy

67.3

 

90

 

97.5

 

Sensitivity

66.9

58.7 to 74.4

89.2

83 to 93.7

98.7

95.2 to 99.8

Specificity

67.6

60.8 to 74%

90.3

85.5 to 94

96.6

93.2 to 98.6

Positive likelihood ratio

2.1

1.7 to 2.6

9.23

6.1 to 14.1

29.2

14.1 to 60.4

Negative likelihood ratio

0.49

0.38 to 0.63

0.12

0.08 to 0.19

0.01

0 to 0.06

Disease prevalence

41.7

36.5 to 47

41.7

36.5 to 47

41.7

36.5 to 47

PPV

59.6

51.8 to 67.2

86.8

80.4 to 91.8

95.4

90.8 to 98.1

NPV

74.1

67.2 to 80.2

92.1

87.5 to 95

99

96.5 to 99.9

  1. BI-RADS Breast Imaging Reporting and Data System, AUC area under curve, PPV positive predictive value, NPV negative predictive value, CI confidence interval