Fig. 1
From: Spectrum of liver lesions hyperintense on hepatobiliary phase: an approach by clinical setting
Top row: schematics showing the uptake mechanism of hepatobiliary contrast agents. Bottom row: corresponding schematics of the signal characteristics of liver and focal observations. Left column: a uptake in hepatocytes and (b) corresponding signal characteristics in normal liver. Middle column: c increased uptake due to overexpression of OATP1B3 and (d) corresponding iso- or hyperintense signal characteristics of focal observations (from left to right: FNH, nodule with hyperintense rim, hyperintense HCC, HCC with nodule-in-nodule architecture and HCC with peritumoral hyperintensity). Right column: e increased uptake due to retention in fibrotic stroma or aberrant expression of OATP1B3 and (f) representative target imaging appearance (lower row) of intrahepatic cholangiocarcinoma or metastasis