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Fig. 14 | Insights into Imaging

Fig. 14

From: Colorectal liver metastases: radiopathological correlation

Fig. 14

Calcifications of liver metastases induced by chemotherapy in a 38-year-old female patient with non-otherwise specified adenocarcinoma of the sigmoid treated with preoperative chemotherapy (FOLFOX and anti-EGFR). Portal venous phase contrast-enhanced CT scan obtained after 12 cycles of chemotherapy (a) shows several liver hepatic metastases with fine calcifications. The preoperative CT-scan performed 12 months later after multiples additional cycles of chemotherapy and right portal vein embolization (b) shows densification of calcifications and the appearance of areas of peripheral tumor regrowth (white arrows). Gross pathology (c) confirmed the presence of calcified (white arrowhead) necrotic metastasis with peripheral viable tumor (white arrows). Histology (d) showed the presence of extensive necrosis partially mineralized with calcium deposits (white thin arrows)

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