Fig. 10

Pre- and post-contrast MRI of the brain in a 55-year-old male patient who presented with rapidly progressive dementia due to sCJD. GRD is seen in the left temporo-parieto-occipital region (arrows) and in the insular regions on axial DWI (a) and ADC image (b). Nearly symmetric restricted diffusion is also seen in the basal ganglia (dashed arrows) along with mild DWI hyperintensity in the pulvinar nuclei (arrowheads). Axial T2W image (c) shows T2 hyperintensity in the basal ganglia (dashed arrows) and pulvinar nuclei (arrowheads). Sequential anteroposterior FLAIR images (d, e) demonstrate the extent of the cortical signal abnormality (arrows). No enhancement is seen in these regions on axial post-contrast T1W image (f)