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Table 1 Gadolinium content in the blood, cerebrum, cerebellum, liver, kidney, skin, and femur (mean values ± SD)

From: Macrocyclic MR contrast agents: evaluation of multiple-organ gadolinium retention in healthy rats

Group (ID)Blood (nmol/mL)Cerebrum (nmol/g)Cerebellum (nmol/g)Liver (nmol/g)Kidney (right) (nmol/g)Skin (nmol/g)Femur (nmol/g)
Control (A)< LOQ< LOQ< LOQ< LOQ< LOQ< LOQ< LOQ
ProHance (B)< LOQa0.144 ± 0.015b0.151 ± 0.0390.361 ± 0.10638.6 ± 25.00.400 ± 0.1128.48 ± 1.87
Dotarem (C)< LOQ0.342 ± 0.045°°°0.315 ± 0.040°°°0.685 ± 0.330°°°172 ± 134°°°0.660 ± 0.202°°°6.28 ± 3.08
Clariscan (D)< LOQ0.377 ± 0.042°°,*0.345 ± 0.053°°°0.823 ± 0.495°°°212 ± 121°°°0.688 ± 0.215°°°9.44 ± 4.01
Gadovist (E)< LOQ0.292 ± 0.047°°°,**,###0.316 ± 0.040°°°1.22 ± 0.664°°°,**,#294 ± 127°°°,*0.999 ± 0.442°°°,**,#16.1 ± 4.51°°°,***,###
  1. n = 5 for control animals; n = 15 for all other groups except “Dotarem, skin” and “Gadovist, right kidney” where n = 14
  2. Significance vs. group B (ProHance): °°p ≤ 0.01, °°°p ≤ 0.005; vs. group C (Dotarem): *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.005; vs. group D (Clariscan): #p ≤ 0.05, ###p ≤ 0.005
  3. a1 out of 15 values > LOQ (0.165)
  4. b7 out of 15 values < LOQ