Diagnostic categories | Clinical significance | Imaging workup options | ||
---|---|---|---|---|
Return to routine surveillance | Alternative diagnostic imaging (i.e., CT or MRI) | Repeat CEUS | ||
CEUS LR-NC | Not categorizable (due to image degradation or omission) | – | ≤ 3 months* | ≤ 3 months** |
CEUS LR-1 | Definitely benign | 6 months** | – | – |
CEUS LR-2 | Probably benign | 6 months** | – | ≤ 6 months* |
CEUS LR-3 | Intermediate probability of malignancy | – | ≤ 6 months** | ≤ 6 months* |
CEUS LR-4 | Probably HCC | Multidisciplinary discussion may be needed for consensus management. If neither biopsy nor treatment is planned: repeat or alternative diagnostic imaging in ≤ 3 months | ||
CEUS LR-5 | Definitely HCC | Diagnosis of HCC. Multidisciplinary discussion for consensus management. | ||
CEUS LR-M | Probably or definitely malignant, not necessarily HCC | Multidisciplinary discussion for consensus management. May include alternative or repeat imaging, biopsy, or treatment | ||
CEUS LR-TIV | Tumor in vein | Multidisciplinary discussion for consensus management. May include biopsy or biomarker correlation to determine etiology of TIV: HCC, ICC, other. |