Fig. 9

Intrametastatic heterogeneity. a Image exemplifying the development of heterogeneity among the cells the liver metastases as the metastases grow (black arrow). Axial CT images acquired during portal venous phase (b, c) in a 77-year-old woman with gastrointestinal stromal tumor acquired during treatment with imatinib. The hypodense metastasis in the liver shows a new intralesional soft tissue nodule at follow up scan (arrow) (c), suspicious for recurrence