Insights into Imaging

Table 2 Spearman correlation coefficients

From: Optimization of pulmonary emphysema quantification on CT scans of COPD patients using hybrid iterative and post processing techniques: correlation with pulmonary function tests

	%LAA-950 per iDose⁴ level
	1	2	3	4	5	6	7
Body mass index
BMI ISP6	− .439*	− .439*	− .429*	− .426*	− .418*	− .405	− .416*
BMI ISP7	− .455*	− .450*	− .450*	− .444*	− .433*	− .444*	− .438*
BMI ISP7d	− .424*	− .424*	− .424*	− .424*	− .408	− .423*	− .404
GOLD stage
GOLD ISP6	.489*	.489*	.489*	.489*	.497*	.513*	.518*
GOLD ISP7	.456*	.467*	.467*	.467*	.492*	.469*	.469*
GOLD ISP7d	.469*	.469*	.469*	.469*	.525*	.492*	.493*
Pulmonary function tests
FEV₁ ISP6	− .458*	− .458*	− .464*	− .465*	− .475*	− .507*	− .510*
FEV₁ ISP7	− .430*	− .442*	− .442*	− .445*	− .471*	− .453*	− .460*
FEV₁ ISP7d	− .475*	− .475*	− .475*	− .475*	− .509*	− .488*	− .493*
FEV₁% ISP6	− .551**	− .551**	− .554**	− .556**	− .564**	− .588**	− .591**
FEV₁% ISP7	− .526**	− .532**	− .532**	− .534**	− .544**	− .539**	− .542**
FEV₁% ISP7d	− .544**	− .544**	− .544**	− .544**	− .590**	− .574**	− .572**
FVC ISP6	.090	.090	.101	.104	.097	.069	.080
FVC ISP7	.125	.109	.109	.114	.092	.122	.115
FVC ISP7d	.101	.101	.101	.101	.053	.105	.105
FEV₁/FVC ISP6	− .809**	− .809**	− .820**	− .823**	− .825**	− .838**	− .845**
FEV₁/FVC ISP7	− .799**	− .800**	− .800**	− .807**	− .812**	− .813**	− .814**
FEV₁/FVC ISP7d	− .814**	− .814**	− .814**	− .814**	− .834**	− .841**	− .838**
CCQ
CCQ ISP6	.499*	.499*	.521*	.521*	.531*	.562**	.579**
CCQ ISP7	.507*	.510*	.510*	.510*	.523*	.550**	.560**
CCQ ISP7d	.566**	.566**	.566**	.566**	.550*	.572**	.607**

ISP IntelliSpace Portal, ISP7d ISP7 with denoising filter, %LAA-950 percentage of lung voxels with attenuation < − 950 HU, BMI body mass index, FEV₁ forced expiratory volume in 1 s, FEV₁% pred forced expiratory volume in the first second as percentage of predicted, FVC functional vital capacity, CCQ Clinical COPD Questionnaire scores
*p < 0.05; **p < 0.001

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