Fig. 16
From: Diffuse smoking-related lung diseases: insights from a radiologic-pathologic correlation
DIP in a 58-year-old heavy-smoker man. a Posteroanterior (PA) radiograph shows reticular opacities and ground-glass attenuation in both lungs, predominantly in the lower lung zones. b Axial CT image shows ground-glass opacities with cystic changes in the lower and mid lobes and lingula. Images show well-defined areas of sparing, creating a mosaic attenuation. Mild areas of reticulation and bronchiectasis are also present, signifying fibrosis. c Large numbers of alveolar macrophages with light brown granules filling the cytoplasm (arrow); mild interstitial lymphocytic infiltrate and mild fibrosis (arrowhead) (H&E, × 200)