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Fig. 11 | Insights into Imaging

Fig. 11

From: Diffuse smoking-related lung diseases: insights from a radiologic-pathologic correlation

Fig. 11

PLCH. a Coronal and b axial CT images in a 30-year-old man show diffuse upper lobe predominant lucencies with basilar sparing. Imaging findings were thought to represent severe confluent emphysema. c Small cysts (asterisk) with nodular aggregates of Langerhans cells in their walls, with a stellate appearance and centered in bronchioles (arrows) (H&E, × 40). d The cells in the nodules have vesicular nuclei and a pale cytoplasm and sometimes with a reniform appearance; some eosinophils are present (H&E, × 400). e CD1a immunostaining highlights the Langerhans cells

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