Table 5 Semi-quantitative Gaucher disease bone marrow involvement scoring systems
Classification | Bone marrow burden (BMB) | Spanish MRI (S-MRI) | Terk | Rosenthal staging | Duseldorf bone marrow disease score | Vertebra-disc ratio |
|---|---|---|---|---|---|---|
Sites | Femurs Lumbar spine | Femurs Lumbar spine Pelvis | Femurs | Lower extremities | Lower extremities | Lumbar spine |
Considerations | Most validated method Correlates with quantitative Modified method allows use of STIR acquisition Confusion with red marrow in younger patients | Less validated Relevance of pelvis imaging is questioned Confusion with red marrow in younger patients | Does not appreciate more reversible changes seen within the axial skeleton Confusion with red marrow in younger patients | Less sensitive than methods including lumbar involvement Confusion with red marrow in younger patients | Correlates with severe disease Less sensitive than methods including lumbar spine | Quantitative region-of-interest based measurement Limited clinical validation data |