Fig. 11
From: Neuroimaging assessment in Down syndrome: a pictorial review
Coronal (a), sagittal (b), and axial (c) T1/3D reconstructions of a 58-year-old Down syndrome patient presenting with new-onset myoclonic seizures and showing imaging findings similar to Alzheimer disease, with diffuse atrophy predominantly involving the temporal mesial (a, c) (grade 4 in the visual rating scale) and parietal structures with ex-vacuo widening of adjacent CSF spaces (b). The clinical and radiological picture allowed the diagnosis of late-onset myoclonic epilepsy in Down syndrome (LOMEDS)