Table 2 Overview of the most studied factors of cryoablation and the immune system in the reviewed papers
From: Cryoablation and immunotherapy: an overview of evidence on its synergy
Most studied factors of cryoablation and the immune system | ||
|---|---|---|
Mice | Â | Total of 28 articles |
 Survival | ↑ | 17/17 |
 Rechallenge of primary tumour | ↑ | 12/12 |
 Reduction in distant metastasis | ↑ | 10/10 |
 Cytokine release | ↑ | 16/17 |
 IFN-y release | ↑ | 16/17 |
 TNFα release | ↑ | 4/5 |
 IL-4 | ↑ | 1/7 |
 IL-10 | ↑ | 1/4 |
 Th1/Th2 cytokine ratio | ↑ | 10/0 |
 CD4+ infiltration | ↑ | 12/16 |
 CD8+ infiltration | ↑ | 14/19 |
 Treg | ↓ | 5/6 |
 NK cells | ↑ | 3/4 |
Human | Â | Total of 17 articles |
 Survival | ↑ | 8/8 |
 Quality of Life | ↑ | 4/4 |
 Cytokine release | ↑ | 6/7 |
 IFN-y release | ↑ | 6/7 |
 TNFβ release | ↑ | 3/4 |
 IL-10 | ↓ | 3/5 |
 IL-4 | ↓ | 3/4 |
 IL-2 | ↑ | 3/5 |
 Th1/Th2 cytokine ratio | ↑ | 5/0 |
 CD4+ infiltration | ↑ | 5/8 |
 CD8+ infiltration | ↑ | 5/8 |
 Treg | ↓ | 2/2 |
 NK cells | ↑ | 4/4 |