Pre-operative apparent diffusion coefficient values and tumour region volumes as prognostic biomarkers in glioblastoma: correlation and progression-free survival analyses

Insights into Imaging

Table 4 Estimated marginal means volumes (cm³) at each tumour regions and subgrouped based on SVZ and cortex involvement (MRI-based classification)

MRI-based tumour region volumes (cm³)	Region	Mean	Std. error	95% confidence interval
MRI-based tumour region volumes (cm³)	Region	Mean	Std. error	Lower bound	Upper bound
I CEL contacting SVZ and infiltrating cortex	Necrosis	10.916	1.745	7.399	14.432
	Enhancing lesion	13.526	2.019	9.458	17.595
	Peritumoural oedema	75.106	7.266	60.463	89.749
II CEL contacting SVZ but not involving the cortex	Necrosis	6.056	6.411	− 6.864	18.975
	Enhancing lesion	10.552	7.417	−4.396	25.501
	Peritumoural oedema	31.095	26.696	− 22.707	84.897
III CEL not contacting SVZ but involving the cortex	Necrosis	6.458	2.199	2.027	10.890
	Enhancing lesion	8.109	2.544	2.982	13.236
	Peritumoural oedema	93.442	9.157	74.988	111.896
IV CEL neither contacting SVZ nor infiltrating cortex	Necrosis	3.546	6.411	− 9.374	16.466
	Enhancing lesion	5.352	7.417	− 9.597	20.301
	Peritumoural oedema	72.747	26.696	18.945	126.549