Fig. 9

Desmoplastic reaction in a 51-year-old patient with pancreatic adenocarcinoma. a Imaging evaluation including an axial fat-suppresed contrast-enhanced T1-weighted dynamic MR image (DCE-MRI, top, left), a time/signal intensity curve analysis (botton, left), a parametric map corresponding to the initial area under the curve (iAUC), and a fusion of axial T2-weighted image fused with a superimposed color-coded map derived from high b value DWI (FUSION) clearly showed a hypoperfunded mass with a pattern of progressive enhancement (curve type 1, red arrows) and no restricted diffusion in the tumor in the fusion image. These findings were secondary to the predominance of fibrosis within the lesion. b Histological analysis (H&E, × 20) confirmed an abundant tumor desmoplastic reaction (asterisks) with clusters of tumor cells (arrow)