Fig. 17

A 71-year-old man with a Gleason 7 prostate cancer (PSA 6.05). A suspicious area with low ADC values was depicted in the left peripheral area (white arrow). The hyperpolarized ¹³C spectra and the time course for the dynamic conversion hyperpolarized [1-13C] pyruvate to lactate following the injection of hyperpolarized pyruvate were revaluated (top, right). Note the change of the MR spectra with the pyruvate quickly reached a maximum at t: 57.3 s (bottom, middle) before being converted to lactate. Compared with the spectrum at t: 18.6 s (top, middle). [Images courtesy of Kayvan R Keshari, PhD. Laboratory Head. Memorial Sloan Kettering Cancer Center]