Fig. 16

Ipilimumab-induced hypophysitis. A 63-year-old male with metastatic melanoma. Initial imaging demonstrates a partially empty sella with an otherwise normal pituitary gland (arrow). After initiation of ipilimumab, there is marked heterogeneous enlargement of the pituitary gland (arrowhead) compatible with ipilimumab-induced hypophysitis. Imaging 6 weeks after cessation of ipilimumab demonstrates resolution of pituitary enlargement (bracket). However, patient now has clinical and laboratory evidence of panhypopituitarism