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Hyperechoic breast images: all that glitters is not gold!
Insights into Imaging volume 9, pages199–209(2018)
Hyperechogenicity is a sign classically reported to be in favour of a benign lesion and can be observed in many types of benign breast lesions such as hamartoma, lipoma, angiolipoma, haemangioma, haematoma, fat necrosis, fibrosis and galactocele, among others. However, some rare malignant breast lesions can also present a hyperechoic appearance. Most of these hyperechoic malignant lesions present other characteristics that are more typically suggestive of malignancy such as posterior shadowing, a more vertical axis or irregular margins that help to guide the diagnosis. Post magnetic resonance imaging, second-look ultrasound may visualise hyperechoic malignant lesions that would not have been identified at first sight and radiologists must know how to recognise these lesions.
• Some rare malignant breast lesions can present a hyperechoic appearance.
• Malignant lesions present other characteristics that are suggestive of malignancy.
• An echogenic mass with fat density on mammography does not require biopsy.
The majority of breast lesions detected by ultrasound are hypoechoic. According to the BI-RADS lexicon , a hyperechoic lesion is defined by an echogenicity greater than that of subcutaneous fat or equal to that of fibroglandular parenchyma. Only 1–6% of breast masses are hyperechoic and the great majority of them are benign. However, malignant lesions can rarely present in the form of hyperechoic images . Hyperechogenicity has a variable histological origin  and has been attributed to the presence of:
Densely grouped adipocytes
Thick bands of fibrosis
Multiple vascular spaces
A heterogeneous and invasive tumour cell contingent
In their original study published in 1995, based on a series of 750 breast nodules detected by ultrasound, Stavros et al.  reported that 42 nodules were hyperechoic and all of them were benign. Hyperechogenicity was the ultrasound parameter in favour of a benign lesion with the highest negative predictive value (100%). In a more recent study published by Linda et al. , retrospective review of a series of 4511 biopsied lesions revealed that 25 (0.6%) were hyperechoic and 9 (0.4%) were malignant.
The differential diagnosis of hyperechoic breast images is based on knowledge of the clinical setting, detailed analysis of morphological features, and comparison with mammography and possibly magnetic resonance imaging (MRI). In this paper, we propose a review of the various hyperechoic breast lesions.
The American College of Radiology  recommends the use of large bandpass linear transducers with a central frequency of at least 10 MHz for breast ultrasound. The frequency is adapted to the nature of the breast volume and the site of the lesion. Total gain and gain at various depths must be modulated to obtain a homogeneous intermediate signal for fat of the premammary zone, mammary zone and retromammary zone. The focal length is adjusted to the depth over the lesion. Two complementary modes can be used:
Harmonic mode: reduces artefacts, improves spatial resolution and the contrast between glandular tissue, fat and breast lesions by increasing the echogenicity of fat, and enhances posterior ultrasound modifications.
Compound mode or real-time spatial compound imaging: improves the signal-to-noise ratio and optimises analysis of lesion margins and the internal echostructure of breast masses. Posterior ultrasound modifications are attenuated.
Benign hyperechoic lesions
Lipoma is a proliferation of mature adipocytes forming a lobular mass clearly circumscribed by a fine fibrous capsule. Lipoma is a common lesion, often unilateral and solitary, and can present as a soft, mobile palpable mass.
On mammography, lipoma presents as a radiolucent lesion with regular margins, surrounded by a fine radiopaque capsule. On ultrasound, lipoma is a homogeneous lesion with variable echogenicity: isoechoic, similar to subcutaneous fat, or more rarely hyperechoic, due to densely assembled adipocytes (Fig. 1). An echogenic mass with fat density on mammography is benign and does not require biopsy [6, 7].
Angiolipoma is a rare benign lesion composed of mature adipocytes associated with a network of small, narrow-lumen vessels typically containing fibrin thrombus. Angiolipoma classically has a superficial topography, in the subcutaneous tissue, and presents as a painless mass . On mammography, angiolipoma presents as a well-circumscribed solid mass or mixed asymmetric density (solid and fat). On ultrasound, angiolipoma is a clearly demarcated, homogeneous, isoechoic to hyperechoic mass with regular margins (Fig. 2). Its superficial topography may be suggestive of the diagnosis, but biopsy is often performed due to its non-specific presentation.
Fat necrosis is the result of direct trauma, infection, surgery or may be secondary to radiotherapy. It can have a variable appearance, comprising areas of macrophage foam cells, siderophages, fibrous changes or even calcification. On mammography, fat necrosis may present as a radiolucent cyst, possibly associated with thick calcifications, a mass or distortion with spiculated or irregular margins. The ultrasound appearance is variable, sometimes hyperechoic, simple cyst, or a complex mass comprising solid and cystic components (Fig. 3a) . The diagnosis can be established by the suggestive clinical setting and demonstration of the fat density content on mammography (Fig. 3b).
Myofibroblastoma is a rare benign tumour composed of bands of spindle cells, separated by bundles of hyalinised collagen of variable thickness. Myofibroblastoma can be observed in women of all ages, but more commonly in older women. Mammography reveals a well-circumscribed, oval-shaped mass , which is rarely calcified. The margins can sometimes appear poorly defined. On ultrasound, it is a solid mass with circumscribed margins that may be either hypoechoic, isoechoic or hyperechoic, suggestive of fibroadenoma. Hyperechoic forms are sometimes attenuating due to their fat content (Fig. 4) . The diagnosis is based on biopsy.
Haemangioma is a vascular tumour, rarely occurring in the breast, usually observed in middle-aged women. It arises from the breast parenchyma or subcutaneous tissue. On mammography, haemangioma presents as an isodense macrolobular or microlobular lesion with circumscribed margins, possibly containing calcifications. On ultrasound, it is an oval-shaped lesion with circumscribed margins, parallel to the skin with variable echogenicity (hyperechoic in 45% of cases) (Fig. 5). On colour Doppler, haemangioma may be hypovascular with a single feeding artery or hypervascular with multiple feeding arteries .
Haematoma is a localised haemorrhage either secondary to trauma or possibly iatrogenic (interventional procedure, surgery). The ultrasound appearance of haematoma depends on the age of the bleeding: echo-free immediately after the injury, hypoechoic at the acute stage, mixed complex appearance at the subacute stage, hyperechoic at the chronic stage (Fig. 6).
Just-developed hematomas can also be ill-defined and hyperechoic.
The mammographic appearance can be misleading and may mimic malignancy. Correlation with the clinical context and clinical interview are therefore essential for diagnosis.
Hamartoma is a painless, mobile mass, composed of variable proportions of glandular, adipose and connective tissue. Mammography visualises a well-circumscribed, oval-shaped mass containing radiolucent fatty zones, alternating with denser zones corresponding to fibrous tissue, surrounded by a clear pseudocapsule. Ultrasound shows a well circumscribed, oval-shaped compressible mass, surrounded by a fine halo. Hamartomas tend to be hypoechoic, isoechoic or mixed, but can sometimes have a hyperechoic appearance depending on the proportion of the various components. Around 12–43% of hamartomas may appear hyperechoic [6, 13]. An acoustic shadow, a mixture of acoustic shadow and attenuation, or an edge effect artefact may be observed (Fig. 7a and b).
Diseases of lactating women
Galactocele corresponds to milk retention in a dilated lactiferous duct proximal to duct obstruction, generally occurring during breastfeeding or shortly after stopping breastfeeding.
Galactocele can also occur in the absence of breastfeeding in women treated by neuroleptic drugs. The appearance of galactocele depends on the fat and protein content.
A galactocele with fat density on mammography has a hyperechoic appearance on ultrasound (Fig. 8a and b).
Lactating adenoma is a benign tumour occurring during the last trimester of pregnancy, composed of dilated tubular structures, forming alveoli of variable size, lined by vacuolated cells containing lipid-rich foamy material in their centres. Mammography shows an oval-shaped mass containing zones of fat, while ultrasound reveals a well-circumscribed, homogeneous, hypoechoic (67%), isoechoic (20%) or hyperechoic (13%) oval-shaped mass. Lactating adenoma usually resolves spontaneously after stopping breastfeeding .
Pseudoangiomatous stromal hyperplasia (PASH)
Pseudoangiomatous stromal hyperplasia is a benign mesenchymal lesion, more commonly observed in premenopausal women or in women treated by hormonal therapy. PASH consists of proliferation of myofibroblasts induced by a high density of progesterone receptors, leading to the development of fibroblastic hyperplasia. PASH is characterised by the presence of a network of anastomotic channels lined by flat, endothelium-like cells, simulating a vascular tumour. These empty channels, devoid of erythrocytes, predominantly present a concentric pattern around lobules and are typically situated in a dense collagen stroma.
PASH may present either as a nodular form (palpable or impalpable) or a diffuse form. The nodular form is rare, observed on less than 1% of breast biopsies. Mammography reveals a well-circumscribed, non-calcified mass or asymmetric density. Ultrasound shows a well-circumscribed, hypoechoic and/or hyperechoic oval-shaped mass (Fig. 9b and b).
Mastitis and breast abscess
Breast abscesses are observed in 5–11%  of breastfeeding women with infectious mastitis, generally caused by penetration of Staphylococcus aureus via a cracked nipple. Breast abscess presents with fever, diffuse or localised erythema of the breast, painful induration and leucocytosis. Smoking increases the risk of breast abscess, which can also occur in non-lactating women (secondary to duct ectasia, cystic inflammation or duct metaplasia) and, more rarely, in men. Mammography shows a well-circumscribed or masked mass, while ultrasound reveals distended ducts with an echogenic content. Although breast abscess may sometimes have an hyperechoic appearance, it generally presents mixed echogenicity (Fig. 10). The diagnosis is usually guided by the clinical context and the favourable course in response to antibiotics. When a breast abscess in a non-lactating woman fails to respond to antibiotics, biopsy should be performed to exclude inflammatory breast cancer (differential diagnosis).
Siliconoma is an inflammatory resorption granuloma arising in contact with droplets of free silicone gel, related to capsular rupture or free silicone injections. On mammography, siliconoma presents as a mass isodense to prosthetic silicone. Ultrasound shows a hyperechoic mass containing fine echoes with marked attenuation of the ultrasound beam, with a “snowstorm” appearance masking all posterior structures (Fig. 11). The diagnosis is guided by the clinical context and the ultrasound features, without the need for biopsy.
Complex sclerosing lesion
Complex sclerosing lesions are benign breast lesions comprising a combination of sclerosing lesions with a variety of proliferative epithelial lesions. Radial scar is a sclerosing lesion with a fibro-elastotic centre surrounded by a radial crown composed of sometimes cystic lobules and ductules, sometimes presenting proliferative lesions. In 30% of cases , radial scar is associated with ductal carcinoma in situ or a tubular carcinoma. On ultrasound, it presents as a poorly circumscribed, round or lobular zone, inducing architectural distortion with variable echogenicity, more often hypoechoic, sometimes associated with posterior attenuation (Fig. 12). The diagnosis of these lesions must be based on histological examination of a percutaneous biopsy. When histological examination reveals a diagnosis of associated cancer, the tumour can be treated immediately (including sentinel node biopsy in the case of invasive cancer). When histological examination is negative for cancer, surgical exploration is indicated to avoid missing a focal malignant lesion not detected by percutaneous biopsy.
Adenosis corresponds to hyperplasia of all constituents of the terminal duct lobular unit (epithelial cells, myoepithelial cells and connective tissue), resulting in increased size and number of lobules. Adenosis may present clinically in the form of slowly growing breast swelling. In most cases, it is not associated with any mammographic signs. Florid adenosis can present with a multimicronodular radiographic appearance. Punctate microcalcifications may also be observed. On ultrasound, adenosis presents as a zone of variable echogenicity, possibly with irregular margins (Fig. 13).
Possibly hyperechoic malignant lesions
Breast cancers, regardless of their histology, are typically hypoechoic. Breast cancer can rarely be hyperechoic, but other ultrasound features are usually also present, suggesting the diagnosis, such as poorly circumscribed margins, irregular shape, posterior attenuation, a more vertical axis . Ultrasound characterisation must take the most pejorative parameter into account.
Invasive ductal carcinoma (IDC)
IDC accounts for 75% of all breast cancers. On mammography, IDC presents in the form of a spiculated mass, asymmetric density or architectural distortion. On ultrasound, IDC classically presents as a hypoechoic mass, although a hyperechoic or mixed echogenicity lesion may be observed (Fig. 14). In the series published by Skaane et al. , 4/194 (2%) of IDCs were hyperechoic. The mechanisms responsible for hyperechogenicity have not been clearly elucidated, but may be related to tumour heterogeneity or the invasion-front-associating thick bands of collagen, adipose tissue and tumour cell proliferation.
Mucinous carcinoma (or colloid carcinoma) is an uncommon entity, accounting for between 1 and 7% of all breast cancers , with an increasing prevalence with age. Mucinous carcinomas can be subdivided into two histological subtypes, pure or mixed, depending on the mucin content . On mammography, mucinous carcinoma usually presents in the form of a well-circumscribed, lobular or microlobular oval mass. Ultrasound classically reveals a hypoechoic or isoechoic, rarely hyperechoic, microlobular mass (Fig. 15).
Invasive lobular carcinoma (ILC)
ILC is the second most common form of breast carcinoma after invasive ductal carcinoma, characterised by tumour cells invading the breast parenchyma either separately or in chains. The most commonly observed mammographic appearance is that of a spiculated mass, but asymmetric density and architectural disorganisations are observed more frequently than in IDC (Fig. 16). As for IDC, ultrasound usually reveals a hypoechoic mass with spiculated margins and posterior attenuation. In contrast, ILC can present atypical characteristics such as the absence of a clearly defined mass or hyperechogenicity. Hyperechoic presentations are 10 times more frequent in ILC than in IDC .
Angiosarcoma is a rare, aggressive malignant tumour, accounting for less than 1% of all breast cancers. Two forms are distinguished: primary angiosarcoma, which is sporadic in young women, and secondary angiosarcoma in an irradiated breast, occurring an average of 6 years after radiotherapy.
Angiosarcoma arises in the breast parenchyma (in contrast to haemangioma). It is a large tumour, often exceeding 3 cm at diagnosis. Mammography reveals a poorly demarcated, non-calcified mass, or focal asymmetric density. On ultrasound, angiosarcoma tends to present as isolated or multiple heterogeneous, hypoechoic, hypervascular masses, with irregular margins. Forty-four percent of angiosarcomas appear as hyperechoic or mixed hypoechoic and hyperechoic tumours  (Fig. 17).
Metastases to the breast are rare, with the most common primary tumours being lung cancer, malignant melanoma, ovarian cancer, thyroid cancer, lymphoma and rhabdomyosarcoma. Mammography shows usually well-circumscribed, non-spiculated masses. Ultrasound usually shows more or less well-circumscribed hypoechoic or sometimes hyperechoic masses (Fig. 18) with attenuation or acoustic shadow. Skin metastases from malignant melanoma are typically hypervascular on Doppler studies.
Primary lymphoma of the breast is very rare, accounting for less than 0.5% of all breast cancers and less than 1% of non-Hodgkin’s malignant lymphomas, predominantly corresponding to diffuse B-cell lymphoma. Secondary lymphoma, more frequent, is associated with extramammary involvement at diagnosis.
Lymphoma is generally observed in old patients, revealed by a painful, palpable mass with local inflammation, sometimes associated with palpable axillary lymph nodes. Mammography reveals an irregular or lobular non-calcified mass. Multiple masses can also be responsible for asymmetric density. Ultrasound usually reveals a more or less well-circumscribed, hypervascular, hypoechoic mass or sometimes a mixed echogenicity mass, with a hyperechoic periphery (Fig. 19). Hyperechogenicity and mixed echogenicity can be seen in about 23% of breast lymphomas. According to some authors, the presence of hypervascularisation in a hyperechoic mass on Doppler ultrasound justifies biopsy [7, 22].
The very great majority of hyperechoic masses of the breast are benign, and the diagnosis is often guided by the clinical setting. Most malignant lesions are hypoechoic compared to fat, especially when using the harmonic mode. However, malignant lesions can sometimes present in the form of hyperechoic or mixed echogenicity images, in which case other signs suggestive of malignancy are generally present: a more vertical axis, irregular shape, spiculated margins, posterior attenuation or hypervascularisation. Second-look post-MRI ultrasound may visualise hyperechoic malignant lesions that would not have been identified at first sight.
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Journo, G., Bataillon, G., Benchimol, R. et al. Hyperechoic breast images: all that glitters is not gold!. Insights Imaging 9, 199–209 (2018) doi:10.1007/s13244-017-0590-1
- Breast cancer
- Breast ultrasound