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Table 2 Overview of the diagnostic performance of individual conventional CMR criteria and Lake Louise criteria for myocardial characterization in AM; articles are listed in chronological order (see specific references in the text)

From: Lights and shadows of cardiac magnetic resonance imaging in acute myocarditis

First author (reference)

Year

N

EGEr

T2 ratio

LGE

2/3 Positive criteria (LLc)

Reference standard

Abdel-Aty [16]

2005

48

Se 80

Se 84

Se 44

Se 76

Clinical/coronary angiography

Spec 68

Spec 74

Spec 100

Spec 95

Acc 74

Acc 79

Acc 71

Acc 85

Röttgen [33]

2011

131

Se 49

Se 58

Se 31

/

EMB

Spec 74

Spec 57

Spec 88

Acc 57

Acc 58

Acc 50

Stensaeth [32]

2012

42

Se 31

Se 57

Se 64

Se 76

Clinical/coronary angiography

Spec -

Spec -

Spec -

Spec -

Acc -

Acc -

Acc -

Acc -

Lurz [30]

2012

70

Se 76

Se 64

Se 74

Se 81

EMB

Spe 53

Sp 65

Spec 65

Spec 71

Acc 70

Acc 63

Acc 71

Acc 79

Šramko [36]

2013

42

Se 40

Se 7

Se 87

Se 53

EMB

Spec 96

Spec 100

Spec 44

Spec 93

Acc 76

Acc 66

Acc 60

Acc 78

Chu [13]

2013

45

Se 66

Se 69

Se 77

Se 80

Clinical/coronary angiography

Spec 90

Spec 100

Spec 60

Spec 90

Acc 72

Acc 76

Acc 73

Acc 82

Francone [31]

2014

57

Se 61

Se 47

Se 60

Se 61

EMB

Spec -

Spec -

Spec -

Spec -

Acc -

Acc -

Acc -

Acc -

Radunski [34]

2014

125

Se 63

Se 76

Se 61

Se 84

Clinical/coronary angiography

Spec 71

Spec 42

Spec 100

Spec 57

Acc 59

Acc 70

Acc 67

Acc 79

Luetkens [21]

2014

66

Se 83

Se 79

Se 75

Se 92

Clinical/coronary angiography

Spec 42

Spec 61

Spec 100

Spec 80

Acc 60

Acc 68

Acc 91

Acc 85

Pooled data

  

Se 60

Se 63

Se 59

Se 77

 

Spec 68

Spec 64

Spec 85

Spec 81

Acc 63

Acc 63

Acc 71

Acc 78

  1. EGEr early gadolinium enhancement ratio = enhancementmyocardium/enhancementskeletal muscle, T2 ratio = signal intensitymyocardium/signal intensityskeletal muscle, LGE late gadolinium enhancement, LLc Lake Louise criteria, Se sensitivity, Spec specificity, Acc diagnostic accuracy, EMB endomyocardial biopsy