Table 3 European Medicines Agency: categorisation of GBCAs according to NSF risk, based on their thermodynamic and kinetic properties [11]
High risk | |
A. Linear non-ionic chelates B. Linear non-ionic chelates | A. gadoversetamide (OptiMARK®), gadodiamide (Omniscan®) B. gadopentetic acid (Magnevist®, Magnegita®, and Gado-MRT-ratiopharm*) |
Medium risk Linear ionic chelates | Gadofosveset (Vasovist®), gadoxetic acid (Primovist®) and gadobenic acid (MultiHance®) |
Low risk Macrocyclic chelates | Gadoteric acid (Dotarem®), gadoteridol (ProHance®) and gadobutrol (Gadovist®) |