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Table 2 Gadolinium based contrast agents—elimination pathway, last reported total number of administrations, occurrences of NSF and volume of excess chelate quantity [11]

From: Revisiting the risks of MRI with Gadolinium based contrast agents—review of literature and guidelines

Gadolinium based contrast agents

Elimination pathway

Number of reports

No. administrations (millions)

Excess chelate in preparation

Unconfounded

Confounded

Omniscan®

(Gadodiamide)

Kidney

438

90

47

25 mmol/L

Optimark®

(Gadoversetamide)

Kidney

7

11

0.8

35 mmol/L

Magnevist®

(Gadopentetate dimeglumine)

Kidney

135

276

95

135 mmol/L

Multihance®

(Gadobenate dimeglumine)

97 % Kidney

3 % Bile

0

8

6

1 mmol/L

Primovist®

(Gadoxetic acid disodium salt)

50 % Bile

50 % Kidney

0

0

0.15

(Not known)

Vasovist®

(Gadofosveset trisodium)

91 % Kidney

9 % Bile

0

0

0.05

(Not known)

Prohance®

(Gadoteridol)

Kidney

1*

2

2.6

1 mmol/L

Gadovist®

(Gadobutrol)

Kidney

1

13

12.3

2 mmo/L

Dotarem®

(Gadoteric acid)

Kidney

1**

11

22.4

0

  1. *Case published on 5 October 2009
  2. **9 years prior to Dotarem administration, the patient had received an unknown GBCA. Case is still under investigation