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Table 2 Patient characteristics

From: The role of MRI in axillary lymph node imaging in breast cancer patients: a systematic review

Author LN imaging analysis Time to surgery (days) n Prevalence N+ Mean age in years (range) T-stage at diag-nosis Histologic type Pathologic analysis
Yoshimura et al. N-N “Preoperative MRI”, n.o.s. 202 40.0 % 55 (30–86) T1-T3 PT, ST, scirrhous, other Sectioned long-axis
Kvistad et al. P-P “Before surgery”,n.o.s 65 37.0 % 59.4 (38–79) T1-T4 IDC, ILC, MC, tubular, adenocarcinoma Histopathological examination n.o.s.
Michel et al. P-P and N-N 2 days (range 1–6 days) 18 61.1 % 53 (22–76) T1-T4 NR LN regarded as positive when tumour cells were present at light microscopy, independent from immunohistochemical staining results.
Harada et al. N-N Mean 1.2 days 33 19.0 % 58 (36–77) T1-T4 PT, ST, scirrhous, medullary, MC, apocrien, SC, spindle cell Sectioned long-axis, H&E staining, conventional microscopic examination
Orguc et al. N-N NR 155 25.8 % 43 (28–76) NR NR NR
Fornasa et al. One LN/ALND/patient 14 days 43 44.2 % 58 (39–78) NR IDC, ILC Position of the LN and long × short axis
He et al. N-N “After MRI”, n.o.s. 79 12.0 % 44 (20–67) NR DCIS, IDC, ILC, lymphoma Each LN MRI removed, residual fatty tissue examined, LN sliced 4-mm sections, 3-μm-thick slices cut from each section, stained with H&E
Scaranelo et al. P-P “After MRI”, n.o.s. 61 43.0 % 53 (33–78) NR NR Embedded in paraffin blocks for histopathologic evaluation n.o.s.
Hwang et al. P-P “After MRI”, n.o.s. 349 26.4 % 51.3 (25–79) Only T1 IDC, ILC, MC, others Intraoperative frozen section, H&E staining. Remaining portions SLNB; sectioning and immunohistological assay
Luo et al. N-N “Preoperative MRI”, n.o.s. 36 57.0 % 53 (30–63) T1-T3 DCIS, IDC, ILC, other Analysed and examined by pathologist n.o.s.
Kamitani et al. P-P and N-N NR 108 23.6 % 54.9 (34–84) Tis-T3 DCIS, IDC,ILC, MC, metaplastic NR
Basara et al. P-P and N-N NR 110 24.0 % Benign 47 (19–73); malignant 43 (29–70) NR IDC, ILC, IDC+ILC, IDC+MC, IDC+pleomorphic, medullary, malignant phyllodes NR
Hieken et al. P-P and N-N ‘Preoperative MRI”, n.o.s. 505 30.1 % with N0i+, 27.3 % without N0i+ 62 (24–91) T1-T4 IDC, ILC, mixed mammary carcinoma, other Pathology was reviewed and the presence and extent of axillary nodal disease was verified n.o.s.
Abe et al. P-P NR 50 32.0 % 59.9 (33–83) T1-T3 IDC, ILC Pathologically confirmed with SLNB or ALND n.o.s.
Li et al. N-N NR 35 42.0 % NR (30–58) T1-T2 IDC, ILC, tubular Parallel slices 2–3 mm thickness and stained with H&E
An et al. P-P ‘Preoperative MRI”, n.o.s. 215 61.4 % 50 (26–83) T1-T3 IDC, ILC, MC, invasive micro papillary carcinoma, metaplastic, medullary Sections stained with H&E
  1. P-P patient by patient, N-N node by node, n.o.s. not otherwise specified, n population size, N+ positive lymph node status, N0i + isolated tumour cells, IDC invasive ductal carcinoma, ILC invasive lobular carcinoma, DCIS ductal carcinoma in situ, PT papillotubular, ST solid tubular MC mucinous carcinoma, SC squamous carcinoma, H&E haematoxylin and eosin, LN lymph node, MRI magnetic resonance imaging, SLNB sentinel lymph node biopsy, ALND axillary lymph node dissection, NR not reported