Table 1 Diagnostic performances of conventional US and a combination of conventional US and USE for diagnosing thyroid malignancy
From: Thyroid nodule ultrasound: technical advances and future horizons
First author, year (citation) | n (% malignant) | Type | Sensitivity (%) | Specificity (%) | Accuracy (%) | PPV (%) | NPV (%) | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
US | US/USE | US | US/USE | US | US/USE | US | US/USE | US | US/USE | |||
Sebag, 2010 [46] | 146 (19.9) | SWE | 51.9 | 81.5 | 97 | 97 | ND | ND | 82.4 | 88 | 88.1 | 95 |
Trimboli, 2012 [49] | 498 (25.3) | SE | 85 | 97 | 54 | 34 | 62 | 50 | 38 | 33 | 91 | 97 |
Ragazzoni, 2012 [52] | 132 (30.3) | SE | 70 | 85 | 92.4 | 83.7 | 85.6 | 84.1 | 80 | 69.4 | 87.6 | 92.8 |
Cappelli, 2012 [51] | 159 (9.4) | SE | 80 | 100 | 75 | 70.8 | 75.4 | 73.6 | 25 | 26.3 | 97.2 | 100 |
Moon, 2012 [37] | 703 (30.8) | SE | 91.7 | 92.2 | 66.7 | 65 | 74.4 | 73.4 | 55.1 | 54.1 | 94.7 | 94.9 |
Unluturk, 2012 [35] | 237 (24.5) | SE | 69 | 41 | 85 | 93 | 81 | 81 | 60 | 67 | 89 | 83 |
Veyrieres, 2012 [50] | 297 (11.8) | SWE | 77.1 | 97.1 | 58 | 55.3 | ND | ND | 19.7 | 22.5 | 95 | 99.3 |
Shweel, 2013 [48] | 66 (24.2) | SE | 92 | 95.4 | 72.9 | 94.8 | 60.1 | 95.2 | 95 | 82.3 | 63.1 | 98.8 |
Russ, 2013 [47] | 991 (6.7) | SE | 95.7 | 98.5 | 61 | 44.7 | 62 | 48.3 | ND | ND | 99.7 | 99.8 |
Garino, 2014 [54] | 108 (30.6) | SE | 61 | 88 | 83 | 77 | 76 | 81 | 61 | 63 | 83 | 94 |
Liu, 2014 [53] | 331 (30.5) | SWE | 76.2 | 87.1 | 83 | 73.9 | 81 | 78 | 66.4 | 59.5 | 88.8 | 92.9 |