Table 3 Characteristics of RCT of NaHCO3 versus saline pre- and post-hydration
From: Contrast-induced nephropathy: pharmacology, pathophysiology and prevention
Author | No. of patients | Procedure | Renal function | Type of CM | NaCl | % CIN NaHCO3 | % CIN NaCl | P value |
|---|---|---|---|---|---|---|---|---|
Merten et al. [41] | 119 | Mixed | SC ≥97.2 | Iopamidol | 154 mEq/l 3 ml/kg/h 1 h in advance, 1 ml/kg/h 6 h post contrast | 1.7 % | 13.6 % | 0.02 |
Briguori et al. [45] | 219 | CAG or peripheral angiography | SC ≥176.8 or eGFR <40 | Iodixanol | 0.9 %, 1 ml/kg/h 12 h before and post contrast | 1.9 % | 9.9 % | 0.019 |
Masuda et al. [46] | 59 | Emergency CAG/PCI | SC ≥97.2 or eGFR <60 | Iopamidol | 154 mEq/l 3 ml/kg/h 1 h advance 1 ml/kg/h 6 h post contrast | 7 % | 35 % | 0.01 |
Maioli et al. [47] | 495 | CAG | eGFR <60 | Iodixanol | 0.9 %, 1 ml/kg/h 12 h before and post contrast | 10 % | 11.5 % | 0.6 |
Adolph et al. [48] | 145 | CAG | ↑SC, mean 132.6 | Iodixanol | 0.9 % | 4.2 % | 2.7 % | 0.61 |
Ozcan et al. [49] | 264 | CAG/PCI | SC ≥106 | Ioxaglate | 154 mEq/l1ml/kg/h 6 h before and post contrast | 4.5 % | 13.1 % | 0.01 |
Brar et al. [50] | 353 | CAG | eGFR <60 | Ioxilan | 0.9 %, 3 ml/kg/h 1 h in advance, 1.5 ml/kg/h 4 h post contrast | 13.3 % | 14.6 % | 0.94 |