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Table 3 Characteristics of RCT of NaHCO3 versus saline pre- and post-hydration

From: Contrast-induced nephropathy: pharmacology, pathophysiology and prevention

Author No. of patients Procedure Renal function Type of CM NaCl % CIN NaHCO3 % CIN NaCl P value
Merten et al. [41] 119 Mixed SC ≥97.2 Iopamidol 154 mEq/l 3 ml/kg/h 1 h in advance, 1 ml/kg/h 6 h post contrast 1.7 % 13.6 % 0.02
Briguori et al. [45] 219 CAG or peripheral angiography SC ≥176.8 or eGFR <40 Iodixanol 0.9 %, 1 ml/kg/h 12 h before and post contrast 1.9 % 9.9 % 0.019
Masuda et al. [46] 59 Emergency CAG/PCI SC ≥97.2 or eGFR <60 Iopamidol 154 mEq/l 3 ml/kg/h 1 h advance 1 ml/kg/h 6 h post contrast 7 % 35 % 0.01
Maioli et al. [47] 495 CAG eGFR <60 Iodixanol 0.9 %, 1 ml/kg/h 12 h before and post contrast 10 % 11.5 % 0.6
Adolph et al. [48] 145 CAG ↑SC, mean 132.6 Iodixanol 0.9 % 4.2 % 2.7 % 0.61
Ozcan et al. [49] 264 CAG/PCI SC ≥106 Ioxaglate 154 mEq/l1ml/kg/h 6 h before and post contrast 4.5 % 13.1 % 0.01
Brar et al. [50] 353 CAG eGFR <60 Ioxilan 0.9 %, 3 ml/kg/h 1 h in advance, 1.5 ml/kg/h 4 h post contrast 13.3 % 14.6 % 0.94