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Table 1 Pharmacological and pharmacokinetic parameters of iodinated CM [23]

From: Contrast-induced nephropathy: pharmacology, pathophysiology and prevention

Generic name (brand name),
year of introduction
mg I per ml Ionic? Monomer? Osmolality mOsm/kg Viscosity mPa·s D min EL min a
Amidotrizoic acid
 (Urografin),
 1955
146 Yes Yes 710 2.2 @ 20 °C 1.4 @ 37 °C 30 120
Ioxitalaminic acid
 (Telebrix),
 1969
350 Yes Yes 2.130 15.1 @ 20 °C 7.5 @ 37 °C c 66
Ioxaglate
 (Hexabrix),
 1979
320 Yes No 600 7.5 @ 20 °C 2.2 @ 37 °C 15 60
Iopromide
 (Ultravist),
 1979
370 No Yes 770 22.0 @ 20 °C 10.0 @ 37 °C 3 (1–5) 120
Iohexol
 (Omnipaque),
 1983
350 No Yes 780 23.3 @ 20 °C 10.6 @ 37 °C c 120
Iotrolan
 (Isovist),
 1988
300 No No 320 16.4 @ 20 °C 8.1 @ 37 °C c c
Ioversol
 (Optiray),
 1989
350 No Yes 790 14.5 @ 25 °C 8.0 @ 37 °C c 96-120
Iomeprol
 (Iomeron),
 1994
350 No Yes 618 14.5 @ 20 °C 7.5 @ 37 °C 10-35 & 90–130 b 110
Iobitridol
 (Xenetix),
 1995
350 No Yes 915 21.0 @ 20 °C 10.0 @ 37 °C c 108
Iodixanol
 (Visipaque),
 1995
320 No No 290 25.4 @ 20 °C 11.4 @ 37 °C 21 120
  1. a Approximate elimination half-life after intravenous injection in patients with normal renal function
  2. b Iomeprol exhibits biphasic distribution with a first short period and a second longer period
  3. c Data after intravenous infusion unknown