Fig. 5
From: Computed tomography of the spleen: how to interpret the hypodense lesion
Transverse contrast-enhanced CT images acquired during the portal venous phase. a A 43-year-old man with advanced sickle-cell disease. Note the irregular shape of the spleen, as well as the increased density of the splenic parenchyma, together with extensive calcifications as a consequence of constantly occurring micro-infarctions. b A 38-year-old man with sickle-cell disease exhibiting end-stage splenic involvement. Note the increased density, calcifications of the shrunken spleen