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Fig. 2a, b | Insights into Imaging

Fig. 2a, b

From: Medical imaging in personalised medicine: a white paper of the research committee of the European Society of Radiology (ESR)

Fig. 2a, b

Novel imaging techniques contribute to personalised diagnosis. Delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) in a patient with complaints of early knee osteoarthritis (a) and a patient without knee complaints (b). With dGEMRIC it is possible to quantitatively assess cartilage quality before the onset of morphological changes, by measuring its glycosaminoglycan content. In patient a, decreased dGEMRIC index is shown particularly in the weight-bearing cartilage of the femoral condyle and tibial plateau compared to patient b. This indicates reduced glycosaminoglycan content, and hence reduced cartilage quality, in the early osteoarthritic knee. Novel quantitative radiological techniques such as dGEMRIC may aid in personalised therapeutic decision-making in early stage osteoarthritis because patients who are likely to benefit from therapeutic interventions can be identified more accurately

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