Disease | Age | CCI | CSTi | CSi | IWMi | Neuroradiologic features | Other features | Evolution |
---|---|---|---|---|---|---|---|---|
CMT X-linked | Young adult | ++ | - | ++ | + | Moose-horn appearance | Stroke-like onset | Reversible |
MSUD | Newborn | - | ++ | ++ | ++ | Already myelinated areas | Severe metabolic decompensation | Variable recovery |
MD | Infant | - | - | ++ | - | Oval/drop-shaped lesions | Severe metabolic decompensation | Persistent T2 lesions |
GA-1 | Child/adult | ++ | - | ++ | -+ | Strip-like appearance of corpus callosum | Also in asymptomatic patients | Persistent on T2 and DWI |
PKU | Child/adult | + | - | ++ | -+ | Prominent parieto-occipital involvement | Also in asymptomatic patients | Persistent on T2 and DWI |
WI | Elderly | - | - | ++ | - | Chain-like appearance | Ipsilateral severe carotid stenosis | Persistent T2 lesions |
GCA | Adult/elderly | -+ | -+ | ++ | - | Extensive bilateral involvement of centrum semiovale | Evocative clinical history | Late necrotic evolution |
Extrapontine myelinolysis | Adult/elderly | + | -+ | + | ++ | Natrium serum level abnormalities | Variable recovery | |
MTX | Child | - | - | ++ | - | Posterior part of centrum semiovale | Clinical history of MTX administration | Reversible |
Inhalation of heroin vapour | Young adult | -+ | + | ++ | + | Extensive bilateral involvement of centrum semiovale | Clinical history of drug abuse | Persistent T2 lesions |
Diffuse axonal injury | Any | ++ | -+ | -+ | -+ | Splenium and undersurface of corpus callosum | Clinical history of head trauma | Persistent T2 lesions |
Reversible lesions of the splenium | Any | ++ | - | + | - | Splenium | Miscellaneous conditions | Reversible |