Local spread | •Local spread into adjacent structures (e.g. pancreas, colon, spleen) |
Lymph node spread | •Perigastric: pericardial; lesser curvature; greater curvature; suprapyloric |
•Extraperigastric: left gastric; common hepatic; coeliac; splenic hilum and artery; hepatic pedicle; retropancreatic; mesenteric root; middle colic; para-aortic | |
Haematogenous spread | •Most commonly the liver (25% at presentation) and peritoneum |
Notes | •Transcoelomic spread can occur through the peritoneum (e.g. Kruckenberg tumours) |
•Retropancreatic, para-aortic and mesenteric nodes are classified as M1 metastatic disease | |
•Nodal disease in GIST tumours is extremely rare |