Fig. 5

Non-specific interstitial pneumonia. a Chest radiograph showed reticulation in the lung parenchyma, diffusely spread in both lungs, centrally and peripherally. b Chest CT showed a crazy-paving pattern especially at the periphery of both lungs. There was an increase in lung attenuation (ground-glass opacification) with a superimposition of a reticular pattern with thickening of the inter- (1) and intralobular (2) septa. c Radiological-histopathological correlation. Histological evaluation showed a homogeneous fibrotic thickening of the interstitium with inflammation. Macrophages were visible within the alveolar septa. Homogeneous interstitial inflammation was seen, corresponding to the diffuse ground-glass opacities, whereas fibrosis in the interstitium and alveolar septa (black arrow) was related to the superimposed linear pattern