Table 1 Comparison of clinicopathological factors between pure DCIS and DCIS with invasive upgrade
| Â | Total DCIS (n = 440) | Mammographically detected DCIS (n = 341) | ||||
|---|---|---|---|---|---|---|
Pure DCIS (n = 323) | DCIS with invasive upgrade (n = 117) | p value | Pure DCIS (n = 238) | DCIS with invasive upgrade (n = 103) | p value | |
Clinical factors | ||||||
 Age (years, median (Q1, Q3)) | 52.0 (45.0, 61.0) | 50.0 (46.0, 59.0) | 0.298 | 53.0 (46.0, 61.0) | 50.0 (46.0, 60.0) | 0.339 |
 Family history of breast cancer |  |  | 0.410 |  |  | 0.483 |
  No | 296 (91.6) | 110 (94.0) |  | 219 (92.0) | 97 (94.2) |  |
  Yes | 27 (8.4) | 7 (6.0) |  | 19 (8.0) | 6 (5.8) |  |
 Personal history of breast cancer |  |  | > 0.999 |  |  | > 0.999 |
  No | 310 (96.0) | 113 (96.6) |  | 234 (98.3) | 102 (99.0) |  |
  Yes | 13 (4.0) | 4 (3.4) |  | 4 (1.7) | 1 (1.0) |  |
 Bilateral DCIS |  |  | 0.006 |  |  | 0.138 |
  No | 263 (81.4) | 108 (92.3) |  | 212 (89.1) | 97 (94.2) |  |
  Yes | 60 (18.6) | 9 (7.7) |  | 26 (10.9) | 6 (5.8) |  |
 Related symptoms |  |  | 0.010 |  |  | 0.018 |
  Asymptomatic | 261 (80.8) | 81 (69.2) |  | 186 (78.2) | 68 (66.0) |  |
  Present | 62 (19.2) | 36 (30.8) |  | 52 (21.8) | 35 (34.0) |  |
 Biopsy method |  |  | 0.009 |  |  | 0.003 |
  Core needle biopsy | 234 (72.5) | 99 (84.6) |  | 159 (66.8) | 85 (82.5) |  |
  Vacuum-assisted biopsy | 89 (27.5) | 18 (15.4) |  | 79 (33.2) | 18 (17.5) |  |
 Tumor size (mm, median (Q1, Q3)) | 14.0 (8.0, 23.0) | 20.00 (12.0, 30.0) | 0.002 | 17.0 (10.0, 26.0) | 21.0 (13.0, 30.0) | 0.012 |
Pathologic factors | ||||||
 Nuclear grade |  |  | 0.001 |  |  | 0.006 |
  Low | 134 (41.5) | 28 (23.9) |  | 84 (35.3) | 21 (20.4) |  |
  Intermediate | 158 (48.9) | 67 (57.3) |  | 126 (52.9) | 60 (58.3) |  |
  High | 31 (9.6) | 22 (18.8) |  | 28 (11.8) | 22 (21.4) |  |
 Comedonecrosis |  |  | 0.012 |  |  | 0.086 |
  No | 151 (46.8) | 39 (33.3) |  | 90 (37.8) | 29 (28.2) |  |
  Yes | 172 (53.2) | 78 (66.7) |  | 148 (62.2) | 74 (71.8) |  |