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Table 4 Descriptive general MRI features of the conventional anatomical whole-body MRI, spinal dynamic contrast-enhanced MRI, and spinal diffusion-weighted imaging of the entire patient population, the intermediate-/high-, and the standard-risk cytogenetic group

From: Predicting cytogenetic risk in multiple myeloma using conventional whole-body MRI, spinal dynamic contrast-enhanced MRI, and spinal diffusion-weighted imaging

 

All patients (n = 31, 100%)

Intermediate-/high-risk (n = 13, 42%)

Standard-risk (n = 18, 58%)

Conventional WB-MRI

 Contrast

23 Gadovist (74%)

12 Gavovist (92%)

11 Gadovist (61%)

1 Dotarem (3%)

 

1 Dotarem (6%)

7 Magnevist (23%)

1 Magnevist (8%)

6 Magnevist (33%)

 Skeletal score

9.0 ± 2.9

9.0 ± 3.0

9.0 ± 2.9

 Pattern general

2 focal only (6%)

2 focal only (15%)

0 focal only (0%)

29 generalized (94%)

11 generalized (85%)

18 generalized (100%)

 Pattern specific

2 focal (6%)

2 focal (15%)

0 focal (0%)

2 salt-and-pepper (6%)

0 salt-and-pepper (0%)

2 salt-and-pepper (11%)

8 diffuse (26%)

2 diffuse (15%)

6 diffuse (33%)

19 focal + diffuse/salt-and-pepper (62%)

9 focal + diffuse/salt-and-pepper (70%)

10 focal + diffuse/salt-and-pepper (56%)

 FL

21 present (68%)

11 present (85%)

10 present (56%)

10 absent (32%)

2 absent (15%)

8 absent (44%)

 FL number

18: 0–4 (58%)

5: 0–4 (38%)

13: 0–4 (72%)

13: 5–20 (42%)

8: 5–20 (62%)

5: 5–20 (28%)

0: > 20 (0%)

0: > 20 (0%)

0: > 20 (0%)

 Largest FL diameter (mm)

21.9 ± 21.8

23.1 ± 28.9

20.8 ± 13.0

 Largest FL volume (mm3)

33.6 ± 116.2

56.7 ± 164.4

10.4 ± 17.9

Spinal DCE-MRI

 TIC type thoracic general

6 slowa (19%)

3 slowa (23%)

3 slowa (17%)

25 steepb (81%)

10 steepb (77%)

15 steepb (83%)

 TIC type thoracic specific

2: I (7%)-4: II (13%)-6: III (19%)-19: IV (61%)-0: V (0%)

1: I (8%)-2: II (15%)-4: III (31%)-6: IV (46%)-0: V (0%)

1: I (6%)-2: II (11%)-2: III (11%)-13: IV (72%)-0: type V (0%)

 TIC type lumbar general

11 slowa (35%)

5 slowa (38%)

6 slowa (33%)

20 steepb (65%)

8 steepb (62%)

12 steepb (67%)

 TIC type lumbar specific

7: I (23%)-4: II (13%)-6: III (19%)-13: IV (42%)-1: V (3%)

4: I (31%)-1: II (7%)-4: III (31%)-4: IV (31%)-0: V (0%)

3: I (17%)-3: II (17%)-2: III (11%)-9: IV (50%)-1: V (5%)

Spinal DWI

 Restriction thoracic general

7 normal (23%)

3 normal (23%)

4 normal (22%)

24 increased (77%)

10 increased (77%)

14 increased (78%)

 Increased restriction thoracic specific

7 normal (23%)

3 normal (23%)

4 normal (22%)

8 mild (25%)

4 mild (31%)

4 mild (22%)

9 moderate (29%)

3 moderate (23%)

6 moderate (34%)

7 severe (23%)

3 severe (23%)

4 severe (22%)

 Restriction lumbar general

9 normal (29%)

4 normal (31%)

5 normal (28%)

22 increased (71%)

9 increased (69%)

13 increased (72%)

 Increased restriction lumbar specific

9 normal (29%)

4 normal (31%)

5 normal (28%)

13 mild (42%)

5 mild (38%)

8 mild (44%)

4 moderate (13%)

1 moderate (8%)

3 moderate (17%)

5 severe (16%)

3 severe (23%)

2 severe (11%)

  1. DCE-MRI Dynamic contrast-enhanced MRI, DWI Diffusion-weighted imaging, FL Focal lesion, mm Millimeter, mm3 Cubic millimeter, n Number, TIC Time-intensity curve, WB Whole-body
  2. aSlow = time-intensity curve type I and II
  3. bSteep = time-intensity curve type III, IV, V