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Table 2 Equilibrium comparison between the training and internal validation sets, and the clinical/radiological characteristics in the external validation

From: Exploring a multiparameter MRI–based radiomics approach to predict tumor proliferation status of serous ovarian carcinoma

Characteristics

Equilibrium comparison

External validation set, n = 42

Training set, n = 93

Internal validation set, n = 41

p value

Clinical characteristics

 Age

53.05 ± 10.83

54.24 ± 10.40

0.554a

54.31 ± 8.30

 FIGO

  

0.098c

 

  I–II

16 (17.2)

15 (36.6)

 

7 (16.7)

  III–IV

77 (82.8)

26 (63.4)

 

35 (83.4)

 CA125

830.50 (307.70, 1856.10)

593.00 (239.50, 2036.70)

0.327b

1000.50 (410.24, 2104.28)

 HE4

396.00 (153.00, 767.00)

224.00 (108.00, 597.00)

0.084b

572.55 (201.58, 960.12)

 NLR

2.87 (1.89, 5.43)

3.26 (2.04, 4.58)

0.186b

3.49 (2.57, 5.36)

Radiological characteristics

 Distribution

  

0.106c

 

  Unilateral

41 (44.1)

25 (61.0)

 

22 (52.4)

  Bilateral

52 (55.9)

16 (39.0)

 

20 (47.6)

 Lobulated ovarian mass

  

0.547c

 

  No

3 (3.2)

3 (7.3)

 

3 (7.1)

  Yes

90 (96.8)

38 (92.7)

 

39(92.9)

 Angiogenesis of ovarian mass

  

0.741c

 

  No

8 (8.6)

5 (12.2)

 

4 (9.5)

  Yes

85 (91.4)

36 (87.8)

 

38 (90.5)

  Size of ovarian mass (maximum diameter, cm)

8.20 (6.00, 12.00)

8.60 (6.80, 11.00)

0.835b

6.20 (4.82, 8.90)

 Homogeneous solid in ovarian mass

  

1c

 

  No

26 (28.0)

12 (29.3)

 

12 (28.6)

  Yes

67 (72.0)

29 (70.7)

 

30 (71.4)

 Peritoneum/mesentery nodules

  

0.837c

 

  No

24 (25.8)

12 (29.3)

 

9 (21.4)

  Yes

69 (74.2)

29 (70.7)

 

33 (78.6)

Metastases of distant parenchymal organs

  

1c

 

  No

79 (84.9)

35 (85.4)

 

35 (83.3)

  Yes

14 (15.1)

6 (14.6)

 

7 (16.7)

 Retro-peritoneal lymphadenopathy

  

0.106c

 

  No

73 (78.5)

26 (63.4)

 

35 (83.3)

  Yes

20 (21.5)

15 (36.6)

 

7 (16.7)

 Amount of ascites

  

0.013c

 

  No/small

38 (40.9)

27 (65.9)

 

20 (47.6)

  Medium-to-large

55 (59.1)

14 (34.1)

 

22 (52.4)

  1. FIGO the International Federation of Gynecology and Obstetrics, CA125 carbohydrate antigen 125, HE4 human epididymis protein 4, NLR neutrophil-to-lymphocyte ratio; Age is presented as means ± standard deviations; CA-125, HE-4, NLR and Size of ovarian mass are expressed as medians (interquartile ranges); other characteristics are expressed as absolute numbers and percentages
  2. aStudent’s t test
  3. b Wilcoxon test
  4. cChi-square test